Physics methods in systems biology
30h lectures + 30h tutorials, winter semester 2020/2021
The course will provide general introduction to living matter (bacteria, cells) followed by specific discussion of gene expression, transcriptional regulation, morphogen spreading and resulting pattern formation in different developmental systems.
The course will equip students with ability to quantitatively describe biological systems at gene and tissue level. The course will discuss how to pick the correct level of modelling details to address specific questions in systems biology context. In the lectures, biological systems will be introduced followed by different theoretical schemes used to model particular system in question. Students will be familiarized with examples of biological systems that include classic ones (regulation in lambda phage, pair-rule genes in Drosophila) and more recent ones with focus on developing systems (Drosophila, Zebrafish embryo, spinal cord development).
The course pre-requisites include basic mathematical calculus and basic experience with differential equations.